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Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica®, Venclexta™, and Empliciti™ — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and small-molecule technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.
Director/Senior Director of Cancer Biology will expand, strengthen and strategically lead a research department at the forefront of cancer biology. The successful candidate will be responsible for championing the future scientific vision and executing the scientific strategy that delivers compelling opportunities to the AbbVie pipeline. This role will be responsible for driving the science and research focused on achieving a deep understanding of tumor biology in the context of multiple technology platforms that can be translated into novel breakthrough therapies. Reporting to the Head of Research at AbbVie Stemcentrx, this position will play a key role on our Research Leadership Team, setting scientific strategy and contributing to successfully achieving cross-functional research goals through collaboration with other internal discovery research functions across sites. Additionally, the Head of Cancer Biology will work collaboratively with our Clinical and Development
Science Organizations, as well as represent Cancer Biology to Core Development Teams.
The ideal candidate should have a strong background in cancer biology and drug discovery, and a track-record of identifying and progressing novel concepts to clinical candidates. As a creative scientist and a critical thinker, this leader should have a stellar record in oncology research, preferably in solid tumors and in an industry setting. As a skilled organizational leader, this individual should be an efficient and accountable manager, an effective team builder and a productive collaborator who will provide strong organizational, technological and scientific leadership to early research, preclinical pipeline programs and platforms, and in support of clinical assets. This person will draw from past team leadership experience to develop the Cancer Biology team and guide the team to accomplish goals through superior performance.
Key Responsibilities Include:
* As the leader for cancer biology efforts, this role will play a substantial strategic role in guiding the scientific direction of research and pipeline programs at AbbVie Stemcentrx, and contribute new ideas to the research platform.
* As a member of the Research Leadership Team, develop and implement Discovery Strategy for AbbVie Stemcentrx.
* Propagate a development-oriented culture and champion the growth of a talented and aspirational team of cancer biologists. Develop and empower talent within the department.
* Identify, engage, and ensure the success of research collaboration across AbbVie’s global R&D network and the external scientific community.
* Maintain high-functioning and synergistic cross-functional relationships across the AbbVie discovery organization.
* Keep up-to-date with the latest scientific advancements (e.g. competitive landscape, new technologies and partnerships) and be well informed about emerging trends in oncology research and development to deliver the next generation of oncology discovery concepts.
* Work with the Research Leadership Team to allocate resources to ensure timely achievement of aggressive pipeline and technology goals.
* Set departmental scientific and business goals and manage people, resources, financial budget and other administrative functions.
* Develop and guide the structure of the Cancer Biology team in order to assure optimal efficiency, teamwork, and utilization of resources.
* Provide day-to-day scientific, technical and organizational leadership for the research teams and manage a portfolio of discovery projects to achieve scientific and operational excellence.
* Promote and foster a science-driven, goal-oriented culture with innovation, accountability, transparency, empowerment and agility.
* PhD in Life Sciences or equivalent with a minimum of 12 years of relevant industrial/academic experience in oncology positions of increasing responsibility.
* Demonstrated expertise in drug discovery from early research through IND-filing and translational science. Experience in progressing multiple pre-clinical candidates to IND approval is preferred.
* Experience in leading a high performing, mid-sized biology/drug discovery group of > 15 people in a biotechnology or pharmaceutical company. Proven record in developing people and fostering creativity, productivity, accountability and execution with a sense of urgency.
* Experience in both a small and large company settings is preferred.
* Demonstrated excellence in strategic planning and project leadership. Decisive problem solver with ability to balance creativity, innovation and probability of success.
* Proven scientific leadership with a track record of scientific innovation and accomplishment in disease biology research and oncology target discovery as evidenced by quality and quantity of publications, patents and conference presentations.
* Track record of developing efficient discovery processes and leading cross-functional team collaborations, including managing relationships with internal AbbVie discovery teams, academic collaborators and CROs.
* Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards and outstanding written and verbal communication skills.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
URL for your website or original job posting:
The role of a Principal Scientist is responsible for the overall conduct of studies in different immune-therapeutic area, overseeing experimental testing design, as well as formulating conclusions and recommendations for next steps. The incumbent has the ability to present Caprion capabilities to clients in a compelling way demonstrating value and differentiation as support function to Business Development activities as well as presentation of results to Sponsor and scientific meetings. The incumbent is ensuring that the timelines and milestones of a study are met by proactively assessing foreseeing challenges, assessing impact of deviations and overall quality of the study conduct.
Oversees the planning and progress of studies and projects under her/his responsibility;
Designs and prepares detailed study-specific work plans and support documentation for IM protocols and assays; discusses with management and obtains approval as appropriate;
Participates in the development of new in vitro assays as per client needs, including the assay qualification and validation phase;
Instructs laboratory personnel (e.g. research assistants and technicians) assigned to her/his projects;
Ensures that projects are conducted as per established timelines and delays are communicated in a proactive manner to clients with action plan to minimize the delays;
Identifies resource constraints and inefficiencies and works with management to resolve;
Prepares preliminary and final reports;
Ensures that all study-related data is appropriately maintained and archived;
Participates in the preparation of presentations and publications in collaboration with clients when possible;
Interacts regularly with clients, clinical sites and Caprion management to address project issues in a timely manner and to the satisfaction of the client. Documents study-related interactions and communications properly;
Actively participates in the preparation and conduct of audits for clients or regulatory bodies.
Ph.D. or equivalent training in life sciences, preferably in immunology, virology, microbiology or molecular biology.
Experience and Skills Required
A minimum of 5 years experience in an equivalent position in the industry;
Knowledge of modern immunology and kept abreast with current literature, IM methodologies and clinical trial design and regulations;
Knowledge and experience with flow cytometry techniques and its generic applications in the field of IM including testing design as well as handling complex data set of multi-color panels;
Knowledge of cell-based assays to monitor adaptive and innate immune responses;
Experience working with FlowJo, Pestle, Spice, Prism and Excel
Knowledge and understanding of GLP regulations and other regulatory guidelines sufficient to carry out GLP studies;
Experience in project management;
Experience with client management;
Strong communication ability;
Bilingual French and English (written & spoken).
Approaches work methodically and systematically;
Establishes priorities from among a number of demands;
Demonstrates and applies advanced level of understanding and analytical skills to interpret data and draw conclusions within the project goals;
Critical and creative thinker;
Communicates clearly and confidently and has excellent interpersonal skills;
Skilled at working in a fast-paced and multi-tasking environment.
Must be willing to perform duties or supervise activities in Bio Safety Level (BSL) 1 or 2 facilities where biological samples may be either naturally or experimentally infected with potentially hazardous viruses such as HIV, HCV, or CMV.
Interested candidates, the following link provides more details:
Email address for applicants: firstname.lastname@example.org
Kleo Pharmaceuticals is an emerging company at the forefront of synthetic organic chemistry and immunology. We are passionate about developing new, innovative small molecule immunotherapies to treat patients with cancer as well as other life-threatening diseases. Our Headquarters is located adjacent to Yale University in the vibrant city of New Haven, CT.
Description of the Role
We are seeking a highly motivated scientist and team player to lead our Cancer Immunology group and make major scientific contributions to advance our product pipeline. This individual will lead research team efforts and develop the strategies, technologies, and procedures to achieve important milestones in program development.
This position will incorporate a mixture of management and laboratory benchwork responsibilities. Accordingly, our ideal candidate will have proficiency in a wide range of laboratory techniques–especially assays using human and/or mouse immune cells, flow cytometry, ELISA, mammalian cell culture. Experience with antibodies and in vivo tumor models is highly desirable. Experience with cutting-edge techniques and technologies in your field is a plus. Immuno-oncology drug development experiment is essential.
Our ideal candidate may be working in either an industrial or an academic environment, but will possess a strong scientific research background and managerial experience. If you are passionate about advancing healthcare and this position is in agreement with your career goals, we would love to hear from you. A relocation package is available for qualified applicants and based upon level of work experience.
PhD in Immunology, Cell Biology, Cancer Research, or related field
5+ years of additional post-graduate and/or pharmaceutical experience in immunology, oncology and/or cell biology is required
Demonstrated record of scientific achievement and innovation (i.e. strong publication record or drug development portfolio)
Robust research experience in immunology assay development using multiple approaches (ie ADCC/CDC assays, FACS, ELISA, other) is essential
Immuno-oncology assay development experience, in vivo tumor models, and as well as a desire to continue in a laboratory-focused role
Proficiency in molecular biology techniques including cloning, transfection, PCR, qPCR is required
Capacity to thrive in a competitive, multi-disciplinary environment
Interested applicants may submit resumes to email@example.com
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health and help fight and cure disease. As a Principal Scientist in Oncology Translational Medicine in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.
We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.
An attractive relocation package is available for non-local candidates.
Main Duties and Responsibilities:
We are seeking a dynamic thought leader in oncology translational medicine to support Medimmune’s growing pipeline of antibody drug conjugates in our Gaithersburg, MD headquarters. The Principal Scientist will provide exceptional scientific and strategic leadership to understand molecular heterogeneity of disease with a focus both on solid tumors and hematology/oncology and will apply this knowledge to the development of biologics at MedImmune.
The Principal Scientist will work with a team of translational medicine leaders, lab-enabled scientists and bioinformatics analysts to mine genomic and proteomic data from internal and external collaborations and clinical trials. The individual will help design, execute, and analyze biomarker data from clinical studies and have a strong background in development of biologics in oncology. An understanding of clinical trial design, regulatory processes, proof-of-concept studies, diagnostics, and biomarkers is required. The Principal Scientist will hold a leadership role on one or more Product Development Teams and in that capacity will focus on developing testable personalized healthcare strategies requiring analysis of research, translational and clinical data. The expected output is high-quality, scientifically-based product development decisions to be communicated to key stakeholders.
This is a high-profile role requiring an individual with outstanding communication and leadership skills. Vital to this role is the ability to build strong relationships with stakeholders in Research, Clinical Development, Biostatistics and other functions within MedImmune/AstraZeneca and to work effectively with external academic collaborators. The individual must be viewed as a strong scientific and strategic leader who can work within a fast-paced organization to translate fundamental insights in the molecular heterogeneity of disease into targeted therapeutic and biomarker hypotheses that can be tested in clinical trials. Strong project management skills and experience with IND-enabling studies and developing clinical protocols are required. The successful candidate is expected to drive the publication of manuscripts in top-tier scientific, technical or medical journals thereby establishing Medimmune’s scientific leadership.
The preferred candidate will have experience in the design and implementation of biomarkers in clinical studies to support development of antibody drug conjugates in oncology.
Experience with predictive biomarkers and precision medicine approaches is highly desired.
Strong collaboration skills are required that enable effective leadership within product development and scientific teams. Must be highly effective in collaborating with external experts.
Must possess outstanding communication skills, both verbal and written, with the ability to deliver scientific information and proposals to audiences at all levels and functions.
This role requires an outstanding record of innovative contributions to translational sciences in oncology as evidenced by a strong publication record including publications in top-tier journals, inventorship on crucial patents/filings and congress presentations.
The successful candidate should be able to work effectively in a matrix team environment, as well as take ownership of multiple projects.
Organizational skills and demonstrated ability to perform quantitative analysis, graph and present data, write technical reports, and prepare biomarker protocols are required.
Experience developing clinical protocols and regulatory documents is highly desired.
The candidate will have demonstrated an ability to commit to goals and to deliver high quality results.
Experience mentoring and/or managing direct reports is a plus.
Education: PhD, MD/PhD, or MD degree in a relevant scientific field (e.g. molecular biology, immunology, cell signaling, bioinformatics).
A minimum of 12 years post-PhD/MD experience in an academic and/or industry setting.
Next Steps – Apply today!
To be considered for this exciting opportunity, please complete the full application on our website. If you know someone who would be a great fit, please share this posting with them.
MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health and help fight and cure disease. As a Senior Director, Toxicology in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.
The Senior Director of toxicology with a focus on safety and translational sciences aspects of ADC drug development. This position will be reporting directly to the Vice President of Global Safety Assessment. An attractive relocation package is available for non-local candidates.
Responsible for the successful operation of activities of major significance (e.g., filing of discovery, mechanistic toxicology projects, INDs and BLAs) to the biologics safety assessment and translational sciences
Global Biologics R &D cross-functional strategic and advisory role as an Antibody Drug Conjugates thought leader
The position will provide strategic support and guidance on ADC safety-toxicology to all project toxicologists as well as other scientists in translational sciences/medicine functions.
Support activities will be on ensuring consistency in nonclinical strategy for early and late stage ADC projects. With respect to late stage projects (Phase II and beyond), focus will be on BLA and label writing, extractables & leachables, safety strategy, regulatory strategy and interactions and post-marketing activities.
Lead to advance the ADC pipeline from early discovery to clinical development, by developing and implementing consistent nonclinical PK/PD and safety strategies
Manages the ADC safety sciences and business strategies, plans and actions and uses broad scientific knowledge and experience to manage the outcomes and actions of a variety of projects across a toxicology functional area.
Responsible for implementing learnings from late stage projects into early stage projects, and for guiding and directing the global implementation of novel translational platforms (e.g. humanized mouse models) to assess ADC and IMT-C combination PK/PD and safety, with the aim to improve translational value and predictivity.
Education: Ph.D. /DVM/DVM-Ph.D. in relevant discipline of biological sciences with specialization in safety sciences with at least 15 years of experience in oncology drug development, including ADC projects
At least 15 years of post-Ph.D. experience with a minimum of 10 years’ experience in Biologics
Must have strong toxicology background (board certification in Toxicology is highly desirable) and drug development experience
The candidate must have a proven record in filing INDs, BLAs etc.
Must have a strong understanding of biologics drug development, oncology (e.g., immunotherapy of cancer), with specialization in ADCs
General Scope, Knowledge, and Qualifications:
Develops and leads Early discovery, early clinical and late stage and plans to advance numerous scientific opportunities.
Creates competitive and breakthrough strategies and plans.
Communicates a compelling vision and sense of purpose in ADCs
Responsible for the overall leadership and operational success of assigned functions, and for successfully integrating these activities with those of other major organizational segments.
Strong leadership and effective management skills
Innovative, creative and able to influence others in a positive manner
Strong communication, organizational and interpersonal skills to work matrix setting, manages projects and team members in a matrix environment.
Problem solving and organizational skills with attention to details related to drug development.
Strong team player and strong motivational skills.
Strong publication record in toxicology/pharmacology
Strong experience in MECHANISTIC AND MOLECULAR TOXICOLOGY of Small and Large Molecule drugs
Applies knowledge of current and future industry trends and how they will affect the business.
Knows the competition and how strategies and tactics work in the marketplace.
Demonstrates broad knowledge and perspective outside of own organizational segment.
Be part of a fast-paced, integrated and interactive research group exploring therapeutics for Oncology, Inflammation and Cancer Immunotherapy programs.
Designing, conducting, analyzing and reporting in vivo and in vitro studies.
Outstanding compensation and benefits. Apply at http://careers.amgen.com/ to job #R-63328.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
The H. Lee Moffitt Cancer and Research Institute is a modern facility in Tampa, Florida. We strive to be the leader in understanding in the complexity of cancer through team science and applying those insights for human benefits. Be part of the cure by joining Moffitt's team of 800 research faculty scientists, career staff scientists, postdocs, graduate students and support staff dedicated to cancer research.
The Research Scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. James Mulé.
Research is focused on experimental strategies to enhance immunotherapy in cancer patients using a variety of in vitro and in vivo immune cell and tumor assays as well as bioengineering strategies.
Opportunities for career advancement through attendance and presentations at nationals and international meetings
The Ideal Candidate:
Experienced scientist with knowledge in techniques and methodologies of Immunology
Familiarity and extensive experience with multi-color Flow cytometry
Experience with immune cell cultures, immunological assays, and processing tissues
Design, plan, and perform experiments with limited supervision
Attend and present work at scientific meetings and seminars
Report and disseminate knowledge gained in the laboratory through public presentation and manuscripts
Promote a collaborative environment within the laboratory and with outside collaborators
Provide supervision and guidance to other lab members with their ongoing projects
Credentials and Qualifications:
Minimum of a M.D. or Ph.D. in Biological Science or related field with three to five years of postdoctoral experience.
The person for the job should have the knowledge as specified by the Investigator.
How to Apply: Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Brittany Palermo at Brittany.Palermo@moffitt.org
We are seeking a talented postdoctoral fellow to conduct basic and translational research projects with the aim of improving anti-tumor immunity in the laboratory of Dr. James J. Mulé at the H Lee Moffitt Cancer Center in Tampa, FL. We have a number of exciting research projects available for both basic and translational work, with ample opportunity to develop additional research avenues in the fields of tumor infiltrating lymphocyte (TIL) therapy, chimeric antigen receptor T cell (CAR-T) therapy, impacting the tumor microenvironment, T cell trafficking, and the induction of tertiary lymph node structures.
Plan and conduct research experiments with limited guidance
Write and submit manuscripts for publication in peer-reviewed journals
Attend and present data at national conferences
Present project updates in department seminars and weekly meetings
Network and liaison with leaders in the biotech industry and with other prominent academic scientists.
The Ideal Candidate will have:
Documented success in research publications and scientific achievement
Established communication skills, and a functional use of the English language in scientific conversation
An established background in basic microbiology, immunology, and/or cancer biology
Experience or willingness to work in preclinical animal models
To organize, plan, and conduct scientific research encompassing one or more projects relating to anti-tumor immunotherapies
To diligently document all research activities
To analyze resulting research data
To create presentation and publication quality figures
To write and prepare scientific manuscripts for publication
To prepare and give scientific presentations
To maintain all necessary trainings and credentials required for relevant scientific research
Credentials and Qualifications:
MD or PhD in immunology, cancer biology, or related field
How to Apply: Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Brittany Palermo at Brittany.Palermo@moffitt.org
The University of Central Florida, College of Medicine is seeking applicants for a tenure or tenure track Assistant, Associate, or Full Professor position in the Department of Internal Medicine. The successful applicant will be an outstanding physician scientist who will conduct independent hematology or oncology research as well as practice clinically in collaboration with our community partners.
UCF is seeking a well-rounded candidate who has demonstrated research excellence and has experience participating in oncology care. The preferred candidate for this position will be serving as a PI on one or more active NIH RO1 or equivalent grants. The ideal candidate will have an interest in collaborating with existing faculty in any of the following areas: Metabolism, Genomics, Immunotherapy, Pediatric Oncology, Neuro-Oncology, and Hematology. The College of Medicine offers a state-of-the-art research infrastructure that includes well-equipped laboratories, robust core resources, advanced imaging equipment, and extensive small animal facilities.
Established in 2006, the UCF College of Medicine is an innovative and forward-looking medical school with a culture of collaboration and partnerships. As a part of a growing “Medical City” dedicated to innovation in health and wellness, the UCF College of Medicine campus has grown to an Academic Health Sciences Center that includes multiple health affairs disciplines, a state-of-the-art research center at the Burnett School of Biomedical Sciences, the fully accredited medical school, multiple clinical graduate medical education programs, UCF outpatient clinics, and the UCF Lake Nona Medical Center under construction. Nearby are the Orlando Veterans Affairs Medical Center, the Guidewell Innovation research incubator, the Nemours Children's Hospital, and the new UCF Lake Nona Cancer Center. Equal Employment Opportunity Employer As an equal opportunity/affirmative action employer, UCF encourages all qualified applicants to apply, including women, veterans, individuals with disabilities, and members of traditionally underrepresented populations. UCF's Equal Opportunity Statement can be viewed at:http://www.oie.ucf.edu/documents/PresidentsStatement.pdf. As a Florida public university, UCF makes all application materials and selection procedures available to the public upon request.
Candidates must have a M.D. or M.D./Ph.D. degree from an accredited school and have three years of experience in faculty level academic positions. Candidates must have demonstrated independent scholarly productivity in oncology research, based on a record of extramural funding success and publications in peer-reviewed journals. Board certification in an appropriate specialty is required, with eligibility for physician licensure in the state of Florida.
In order to be eligible for an appointment as a tenured associate or full professor of medicine upon hire, the successful candidate must have a demonstrated record of scholarly achievement, teaching experience and service commensurate with rank.
Preferences: The preferred candidate for this position will be serving as a PI on one or more active NIH RO1 or equivalent grants. The ideal candidate will have an interest in collaborating with existing faculty in any of the following areas: Metabolism, Genomics, Immunotherapy, Pediatric Oncology, Neuro-Oncology, and Hematology. Additional Application Materials Required:
All applicants must apply through www.jobswithucf.com. In addition to the online application, candidates must also submit a cover letter, a CV, a brief statement outlining their research interests and plan, and the contact information for three professional references, including capacity of the relationship.
NOTE: Please have all documents ready when applying so they can be attached at that time. Once the online submission process is finalized, the system does not allow applicants to submit additional documents at a later date.
Please contact Brittany Hofmann, Brittany.firstname.lastname@example.org, with questions about the position.
Apply Here: http://www.Click2Apply.net/dhhsmr7swvnd8dw9
The Department of Immunology at The University of Texas MD Anderson Cancer Center is seeking applications for a term tenure-track faculty position at any level. We are seeking highly motivated individuals with a strong interest in fundamental immunology research as it relates to cancer. Candidates should demonstrate a record of high-level publications and a history of or strong potential for peer-reviewed research funding. Innovative investigators with immunology experience are welcome to apply.
The position offers the opportunity for scientific and professional growth and development with an exciting and active group of scientists whose diverse research interests comprehensively span the field of immunology. Located in a 132,000 sq.ft. research building, the department hosts state-of-the-art flow cytometry, CyTOF, single-cell sequencing, two-photon imaging, transgenic and gene-targeting, protein expression, hybridoma, and histology facilities. Our faculty study cellular and molecular mechanisms of innate and adaptive immunity. MD Anderson offers excellent opportunities for collaboration with clinicians, allowing investigators to translate their fundamental research to the cancer problem.
Competitive start-up packages will be provided to successful candidates. Houston, home of the Texas Medical Center with a wealth of exciting basic and clinical research across 54 institutions, offers an affordable cosmopolitan living environment and is ranked as the most diverse major city in the United States.
Interested applicants should submit their cover letter, current curriculum vitae, research plan, and contact information for three references to:
The University of Texas MD Anderson Cancer Center
Attn: Misty Hajek
Research Department Administrator
7455 Fannin Street, Suite 3.2013
Houston, TX 77054
MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, religion, age, national origin, sex, sexual orientation, gender identity/expression, disability, veteran status, genetic information, or any other basis protected by federal, state, or local laws, unless such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.
The National Cancer Institute (NCI) is seeking candidates with a medical degree and experience in cancer immunotherapy for the position of Supervisory Physician (GP-602-15), Branch Chief of the Immuno-Oncology Branch (IOB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).
The candidate will serve as a Supervisory Physician/Branch Chief directing the activities of the IOB (https://dtp.cancer.gov/organization/iob/default.htm) and will collaborate with investigators of the DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functions of the branch including planning, designing and executing preclinical research and clinical development of immunotherapy agents through a cross-functional collaboration within DTP and DCTD. As a senior advisor to the Division Director and Institute Director, the candidate will set priorities for federal investment in the development of new methods, technologies, and treatment paradigms that integrate immunomodulation strategies into clinical studies. The candidate is expected to manage and coordinate a system of grants and contracts to discover, investigate, develop and bring to initial clinical trials novel immuno-oncology products.
This is an exploratory ad to gauge interest and develop a possible candidate pool.
A vacancy announcement to fill the position will be posted on www.usajobs.gov at a later date.
This is a full-time government position. Compensation for this position will commensurate with the individual’s qualifications and experience as permitted within Federal government appointments. Individuals who apply must be U.S. citizens.
Please submit your resume, a statement of interest, and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at email@example.com or at (240) 276-5465 to address questions regarding this position.
DHHS, NIH, and NCI are Equal Opportunity Employers
The Research Scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. Shari Pilon-Thomas.
Research is focused on strategies to enhance Tumor Infiltrating Lymphocyte (TIL) therapy in patients
Experience with T cell culture, immunological assays, and processing human blood cells
Provide supervision and guidance to other lab members with their ongoing projects
Interested parties should submit their cover letter and CV to Dr. Pilon-Thomas using the following contact information:
Moffitt Cancer Center
Attn: Shari Pilon-Thomas, PhD
12902 Magnolia Drive
SRB-3, Immunology Department
Tampa, FL 33612
Apply directly at the following link: https://bit.ly/2QSOa9P
AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. Together with its wholly-owned subsidiary, Pharmacyclics, AbbVie employs more than 29,000 people worldwide and markets medicines in more than 170 countries. At AbbVie, our vision is to be recognized as a biopharmaceutical company delivering a consistent stream of innovative medicines that solve serious health issues and have a remarkable impact on people’s lives.
To be successful, we need outstanding individuals willing to challenge themselves to find the best solutions for our patients. The AbbVie Postdoc program is one way we are doing just that.
Through our Postdoc program, we are hiring postdocs from key academic institutions for preferred areas of science in the U.S., while providing a unique opportunity for participants to build a solid career foundation in the pharmaceutical industry while building the AbbVie brand as an employer of choice for scientific talent. The program offers a balance of structured learning and work experience, with accessibility to high-level knowledge building across the drug development continuum to help participants understand how everything fits together and is put into practice. It also provides them with a chance to establish working relationships with some of the world’s most respected scientists and leaders in the industry. Participants in the Postdoc program play an integral part in our continued success and will help us to further grow as a leader in our industry. This assignment is expected to be two years, minimally, and no more than three years.
AbbVie is at the forefront of cancer research, discovering and developing the next generation of treatments to address unmet medical need for cancer patients. Our strong pipeline includes both small molecule and biologic therapeutic approaches with first in class agents that target multiple pathways central to the growth and survival of both solid and hematological malignancies.
We are seeking a highly motivated postdoctoral scientist with a proven track record of research accomplishments to join our growing cancer research organization. The scientist will join a team dedicated to identify and validate targets associated with immunogenic cell death pathways.
Champion efforts to apply functional genomic screening technologies and chemical probes to identify and validate targets associated with immunogenic cell death pathways
Develop and maintain appropriate in vitro assays to measure immunogenic cell death phenotypes
Investigate the biological pathways and cross talk between tolerogenic and immunogenic cell death while developing a publication-driven research program.
Communicate results to multi-disciplinary teams
Successful completion and defense of a PhD in Cancer Research, Immunology, or related field
Demonstrated record of scientific achievement (i.e. strong publication in a top tier peer review journal(s)
Extensive laboratory research experience and desire to continue in a laboratory focused role.
Demonstrated experience in immunology/oncology with a strong working knowledge of innate and adaptive immune cell biology and tumor/immune cell interactions
Ability to independently develop novel assays and cellular models for interrogation of immunogenic cell death
Proficiency in standard biochemical, cellular and molecular techniques
Ability to multitask and work with timelines
Ability to thrive in a fast paced, multi-disciplinary environment interacting with a diverse group of experts within or outside of scientific discipline.
Enthusiasm and passion for conducting creative scientific research
Work authorization in the United States
Effective communication and teamwork skills
Excellent problem-solving skills including critical and analytical thinking.
Demonstrated scientific writing skills and strong verbal communication skills.
Proven track record of teamwork, adaptability, innovation, initiative, and integrity.
Global mindset to thrive in a diverse culture and environment. Demonstrated scientific writing skills and strong verbal communication skills.
Global mindset to thrive in a diverse culture and environment.
Key Leadership Competencies:
Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance
Learns fast, grasps the "essence" and can change course quickly where indicated
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest
Embraces the ideas of others, nurtures innovation and manages innovation to reality
For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com. Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page. Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Center for Immuno-Oncology (CIO) is accepting applications for a scientist to coordinate and direct basic and translational biomarker research in immune oncology.
Qualified individuals will have a MS or PhD with experience in a basic science or translational clinical research laboratory and evidence of academic productivity. Such an individual will work closely with the medical directors of the CIO to develop tissue-based biomarkers to guide patient selection and therapies in the field of cancer immunology. Responsibilities will include overseeing 3 laboratory technicians, reviewing and preparing data, presenting at the weekly group meetings of the CIO and at national meetings, and contributing to high-impact publications. Such an individual oversee the transition of diagnostic tests developed by the CIO into clinical practice at the Center for Advanced Molecular Diagnostics (CAMD) at the Dana-Farber/ Brigham & Women's Cancer Center.
The CIO is multi-disciplinary group that includes investigators in basic and clinical research and dedicated to the discovery, development, and application of novel diagnostics and therapies in cancer immunology. A preferred candidate will be comfortable working independently and collaboratively and have strong management skills. Experience with the laboratory techniques used to study primary tissue samples, flow cytometry, gene expression profiling, and next-gen sequencing, is desired.
Advanced degree in Immunology, Molecular Biology, or related required.
3-5 years experience post education; one year management responsibility required. Level of Skill and Knowledge:
Basic tissue culture and molecular biology skills (e.g. qPCR, PCR) required
Flow Cytometry and ELISA/Luminex assays knowledge required
Mass Cytometry (CyTOF) preferred
Advanced knowledge of Flow Cytometry data analysis (e.g. FlowJo, Cytobank) required
Theoretical and practical knowledge of Next Generation Sequencing sample preparation workflows and applications and experience Ion Torrent sequencing platform is preferred.
Immunology and/or Oncology research experience preferred.
Must have excellent personal task management skills and high level of self-motivation
Excellent verbal and written communication skills and willingness to collaborate cross-departmentally required.
Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought. Works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors. Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
Scope of Leadership and Level of Supervision
Manages the work efforts of one or more technicians. Is responsible for mentoring. Completes performance appraisals. Works closely with senior managers and directors on unit/lab issues. Wide latitude for decision-making working in conjunction with PIs.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Apply Here: http://www.Click2apply.net/cv8y5qsxmv5w5nm2
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie Biotherapeutics, AbbVie's immuno-oncology center in Redwood City, CA.
With appropriate supervision, manages the design and implementation of study protocols for a clinical development program in support of the overall Product Development Plan, based on strong medical and scientific principles, knowledge of compliance and regulatory requirements, AbbVie’s customers, markets, business operations and emerging issues. Oversees project-related education of investigators, study site personnel and Abbvie study staff. Responsibility will focus on early clinical development program activities but may extend to later stage development activities and product lifecycle management strategies for internal programs
Key Responsibilities Include:.
* Responsibility for review, interpretation, and communication of accumulating data pertaining to safety and efficacy of the molecule. Along with Clinical Operations, may be responsible for oversight of study enrollment and overall timelines for key deliverables.
* Contributes to design, analysis, interpretation and reporting of scientific content of protocols, investigator Brochures, Clinical Study Reports, regulatory submissions and responses and other program documents.
* May be asked to contribute to the development of a rigorous, cross-functionally-aligned, vetted Clinical Development plan in collaboration with matrix team members.
* Participates in opinion leader interactions related to the disease area(s); partners with Research, Medical Affairs, Commercial and other functions in these activities as required, consistent with corporate policies.
* Stays abreast of professional information and technology through conferences, medical literature and other available training, to augment expertise in the therapeutic area.
* Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements. May be asked to contribute to regulatory responses and discussions.
* Ensures adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures and to all other quality standards in conducting research.
* PharmD/PhD with 4+ years pharmaceutical industry experience.
* Oncology development experience, specifically early development, is highly preferred.
* Ability to provide input and direction to clinical research with appropriate supervision.
* Strong desire to collaborate in a cross-functional setting.
* Clinical of early phase clinical trial experience in the pharmaceutical industry, academia, or equivalent is preferred.
* Knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials and experience in the design of study protocols is desirable.
* Ability to interact externally and internally to support global scientific and business strategy.
* Must possess excellent oral and written English communication skills.
Job Contact Information: firstname.lastname@example.org, Tim Silcott, 650-296-4528
Dr. Yagi’s digital pathology laboratory at the Josie Robertson Surgical Center serves as an incubator to explore and evaluate new technology to advance digital pathology in a clinical setting and actively engage vendors to help improve the technology and develop clinical applicability. The practical use of digital pathology for primary diagnosis requires the development of useful analytic algorithms to compensate for the reduced efficiency of slide review inherent in current digital slide interface applications, and at MSK, we are uniquely positioned to develop these algorithms while addressing the user experience. Collaborations with clinical departments (e.g., Surgery), Radiology, Medical Physics, and Informatics groups will enhance the assessment and create opportunities for multidisciplinary applications. Your role as Research Fellow in Dr. Yagi’s laboratory is critical to our research and development.
Unless agreed upon in advance to your appointment at MSK, the Research Fellow is expected to work Mondays – Fridays; 9am to 5pm. You will be assigned a workstation in Dr. Yagi’s laboratory located at:
Josie Robertson Surgical Center
Room – JRSC 1020
1133 York Avenue
New York, NY 10065
Research Fellows at MSK are allotted 20 personal days that can be used upon written request and approval from Dr. Yagi at minimum one week in advance of desired dates. Sick and emergency days needed require proper call out protocol as per the Pathology Department and MSK’s policies on attendance and time away.
Research Fellows are also allotted the National Holidays; which are separate from the 20 days above:
New Years Day – Jan 1
Memorial Day – last Monday in May (date varies yearly)
Independence Day – July 4th
Labor Day – first Monday in Sep (date varies yearly)
Thanksgiving Day – third Thursday in Nov (date varies yearly)
Christmas Day – Dec 25th
Time needed to attend conferences and work related events will be discussed and coordinated in advanced and also require prior approval from Dr. Yagi, department administration, and/or MSK administration; as applicable.
Meetings and Conferences:
Annual Symposium for the Warren Alpert Center for Digital and Computational Pathology at MSK. The Research Fellow will be expected to present at MSK twice during their academic appointment:
Fall – internal presentations to MSK pathology faculty and staff; MSK clinicians; and invited guests
Spring – year end presentations of final research projects to MSK faculty and staff and opened to registrants
Weekly 1:1 meetings with Dr. Yagi for 30 mins.
This is your time to check in with Dr. Yagi for feedback on your projects and/or to communicate updates, challenges, issues, and/or concerns.
Biweekly Team Meetings – Every other Friday (10:30am-12pm)
All members of Dr. Yagi’s team are expected to present updates on their research projects following the provided format and time allotted.
Monthly Journal Club Meetings – Third Wednesday (3pm – 4pm)
Journals and topics in the field of digital and computational pathology are presented and discussed. The Research Fellow is highly encouraged to give one presentation; discussed and approved with Dr. Yagi in advance.
The Research Fellow is required to attend these meetings; unless approved in advance by Dr. Yagi to not attend.
Working Group Meetings – Ad Hoc and as needed
The Research Fellow is expected to attend all working group meetings for the research projects he/she is leading and/or collaborating.
The Research Fellow is expected to coordinate working meetings with the MSK pathologists, MSK clinicians, etc as it pertains to his/her assigned projects. If assistance is needed; the Research Fellow can coordinate with Dr. Yagi’s research coordinator; Christina Virgo. The Research Fellow is responsible for the action items and follow up to ensure projects progress in a timely manner.
Deliverables at Completion of Research Fellowship:
The Research Fellow is expected to present an abstract by December for review; to be submitted to USCAP.
The Research Fellow is expected to publish shortly after USCAP; assuming the abstract was accepted. Drafts of publications are due to Dr. Yagi by end of March for review. The Research Fellow is to identify the journals for which he/she will submit; if not already discussed before hand with Dr. Yagi.
Develop a Manuscript and or Standard Operating Procedure Manual to go hand in hand with your research project; as applicable. Dr. Yagi expects detailed written documentation of all testing and validation results; which are to be saved and stored in a central location as identified by Dr. Yagi.
Team Work and Collaboration:
All Research Fellows are expected to work collaboratively with all members of Dr. Yagi’s team and collaborators both internally and externally. Professionalism is expected at all times as you are a representation of Dr. Yagi’s laboratory, the Warren Alpert Center for Digital and Computational Pathology, the Department of Pathology, and the MSK team!
Communication is key; as is accountability! As you’ll quickly learn working in Dr. Yagi’s laboratory; most projects will overlap and we rely on each other’s expertise to obtain optimal results. We also have biweekly team meetings where each member is expected to present an update on their current project. This is an opportunity for Dr. Yagi and your team members to learn more about your project and progress and provide feedback.
If there are ever any issues and/or concerns; please discuss them with Dr. Yagi immediately and/or reach out to your Human Resource partner at MSK.
Confidentiality and Proper Disclosure:
All Research Fellows are expected to abide by MSK’s policies and procedures as it pertains to confidentiality and proper disclosure for possible conflicts of interests. It is the Research Fellow’s responsibility to disclose any and all possible conflicts of interests as per MSK’s policies. All Research Fellows are expected to review the policies and procedures on this matter upon starting in Dr. Yagi’s laboratory. If you have any questions and/or concerns or aren’t sure if a policy pertains to you – please ask us!
Interested applicants can contact Jennifer Samboy, email@example.com.
We look forward to having you as part of our team this year!
The candidate will serve as a Supervisory Physician/Branch Chief directing the activities of the IOB (https://dtp.cancer.gov/organization/iob/default.htm) and will collaborate with investigators of the DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functions of the branch including planning, designing and executing preclinical research and clinical development of immunotherapy agents through a cross-functional collaboration within DTP and DCTD. As a senior advisor to the Division Director and Institute Director, the candidate will set priorities for federal investment in the development of new methods, technologies, and treatment paradigms that integrate immunomodulation strategies into clinical studies. The candidate is expected to manage and coordinate a program that includes grants and contracts to discover, investigate, develop and bring to initial clinical trials novel immuno-oncology products.
A vacancy announcement to fill the position is posted on www.usajobs.gov. To apply, please visit: https://www.usajobs.gov and search NIH-SR-DH-18-10270590.
This is a full-time government position. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal government appointments. Individuals who apply must be U.S. citizens.
DHHS, NIH and NCI are Equal Opportunity Employers.
The EACRI, a division of the Providence Cancer Institute, at the Robert W. Franz Cancer Center invites applicants for full-time faculty positions in Immuno-oncology. The rank is open and will depend on the candidate’s research accomplishments. We are seeking energetic, creative and innovative individuals to complement a strong team of cancer immunologists. Applicants must hold a PhD and/or MD degree in immunology or related discipline. Applicants can be an established investigator with a strong record of published research in immunology and demonstrated success in garnering external funding or a junior faculty candidate with a clear vision of how to establish a funded, productive research laboratory. Competitive start-up funding is available. Additional information on our Institute can be found at www.franzcancer.org.
Apply now by sending your curriculum vitae, a one page description of current and future research interests, and names and contact information of three references to firstname.lastname@example.org.
The Markowitz lab is seeking a Postdoc Fellow or Research Scientist whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
The lab’s research interest is in studying immune suppressor cells, their role in the development of melanoma, and means of inhibiting their actions. We are also developing tools to predict which patients are likely to fail immune-based therapy via novel high dimensional flow cytometric, mass spectrometry and informatics techniques, allowing those patients to be treated with other potentially more effective therapies. We are a translational laboratory striving to translate the knowledge gained in the laboratory via immune-based and traditional biochemical approaches to the clinic. https://moffitt.org/providers/joseph-markowitz/
The postdoctoral fellow/research scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. Markowitz.
Develop biomarkers for immune-based therapy.
Study resistance mechanisms to immune checkpoint blockade.
proficiency in flow cytometry, IHC, immunoblot, cell culture techniques, general immunology
comfortable with murine experiments,
general proficiency in computers, general familiarity with bioinformatics and statistics preferred.
Manage projects under general supervision.
General laboratory techniques such as flow cytometry, murine experiments, informatics (assistance will be given with coding, but need to understand the basics to apply it and make small changes), immunohistochemistry, immunoblots, cell culture, ELISA, proliferation assays, immunoprecipiation
Technical writing of research papers and assistance with grants.
M.D. or Ph.D. in Immunology, Bioinformatics, Cancer Biology
Research Scientist required having a minimum of 3 years as a Postdoc Fellow.
A competitive salary and benefits package will be offered to the successful candidate.
Moffitt is located in Tampa, Florida, which is a thriving city with a low cost of living, excellent culture and outstanding restaurants, and a high quality of life. This position requires someone who can appreciate the sunshine, the nation’s top beaches, and year-round golf, biking, boating, fishing, tennis, swimming, snorkeling and other recreational activities that are associated with the Gulf Coast of Florida.
To formally apply: visit https://moffitt.org/careers-education/. Interested applicants should attach a single PDF file that includes a current CV and cover letter expressing interest with this position to either the Postdoc req 27406 or Research Scientist Req 27435.
AbbVie Stemcentrx is currently offering a unique opportunity for a highly motivated individual to join our team as a Director, Companion Diagnostics Pathology. The Companion Diagnostics Pathology Group resides within the Companion Diagnostics Center of Excellence (CDx COE), which supports CDx development across Abbvie. The successful candidate will provide leadership and expertise in human disease pathology and molecular pathology to support the clinical development of tissue-based companion diagnostics for oncology drug candidates. As a member of the development project teams he/she will have the opportunity to work in a highly collaborative environment and to support projects throughout clinical development.
Key Responsibilities Includes:
* Lead the identification and development of tissue-based biomarkers, including their characterization and validation (biomarker prevalence, clinical utility for patient selection/stratification, relevant cutoffs, etc.) and the proposed pathology assays (specificity and sensitivity, scoring system, etc.)
* Design, implement and oversee pathology based biomarker and diagnostic testing and data analysis for clinical development studies:
o Direct the development, outsourcing and validation of clinically applicable tissue based assays. Assists in the development of assay protocols as needed.
o Write the relevant pathology based biomarker and diagnostics testing sections in drug development and registration documents such as clinical study protocols, clinical study reports, investigator brochures, and regulatory submission packages (INDs, NDA’s,BLA's).
* Provide pathology input to development project teams and ensure access to state of the art tissue based techniques and samples for target pathway evaluation in human disease:
o Implement technologies and/or methodologies as needed, via a combination of in-house efforts and the use of CROs or other external expertise using techniques such as in situ hybridization, immunohistochemistry, IHC multiplexing, fluorescence applications, use of image analysis algorithms, laser capture microdissection, RNAseq, qPCR, etc.
o Evaluate the scientific basis and clinical applicability of the proposed assays, their validation status and any related technical issues.
o Assume responsibility for the assessment and scoring of specimens and the preparation of reports summarizing the data, analysis and interpretation of findings.
o Collaborate with project teams from concept to reagent generation to quantitation and approval plan for CDx as needed.
* Participate in the evaluation of external licensing or collaborative opportunities (including CDx collaborations), and oversee internal components of shared programs.
* Lead and participate in project development teams or sub-teams as needed. Coordinate with appropriate team members to advance projects efficiently.
* Highly experienced pathologist (MD, PhD, or DVM degree) with 8+ years of relevant post-doctoral academic, clinical and/or industry pathology experience. Board certification in the United States is desirable but not required.
* In depth experience with the discovery, characterization, clinical validation and utilization of tissue based biomarkers and potential diagnostics:
o Awareness of the challenges of implementing tissue based biomarker and diagnostic technologies in the clinical setting
o Direct experience in development, outsourcing and validation of clinically applicable tissue based biomarker assays
* A proven Molecular Pathology track record with credible publications and Pathology support for research and clinical science:
o Demonstrated expertise in tissue-based analysis such as in situ hybridization, immunohistochemistry, fluorescence applications, laser capture microdissection
o Expertise with human diseases and evaluation of disease pathogenesis with tools such as experimental mouse models
o Expertise with image analysis software and algorithm design
* Demonstrated excellence in independently leading and conducting research and ability to summarize information/data in a concise, easy to understand manner
* Excellent leadership skills including mentoring, motivation and delegation
* Excellent verbal and written communication and presentation skills in English
* High level of initiative and ability to work independently
* High level of business awareness
About USUHS: The mission of the USUHS is to educate, train, and comprehensively prepare uniformed services health professionals, scientists, and leaders to support the Military and Public Health Systems, the National Security and National Defense Strategies of the United States, and the readiness of our Uniformed Services. USUHS is integral part of F. Edward Hébert School of Medicine. Within campus, we collaborated with Armed Forces Radiobiology Research Institute and with Murtha Cancer Center, Walter Reed, capital Breast care project. USUHS is located in close proximity to National Institute of health, providing opportunities for cross campus collaboration. More info: https://www.usuhs.edu/
Core facilities at USUHS: https://www.usuhs.edu/research/core-facilities
About Geeta Upadhyay: Dr. Upadhyay recently joined USUHS faculty as tenure track faculty. Dr. Upadhyay received her training at Harvard, NCI, UTHSCSA, Georgetown University. Her research is focused on biomarker discover, drug development and drug resistance in breast cancer.
Click here for a complete list of publications.
PROJECT DESCRIPTION: The postdoctoral candidate will have the opportunity to conduct some of the research described in our newly funded R01 grant title “Role of Ly6K in TGF-beta and immune escape pathways of triple negative breast cancer”. Ly6K, a GPI anchored protein, is expressed in cancer tissue and is required for in vivo tumor progression. We have shown that Ly6K activates TGF-beta signaling, epithelial-to-mesenchymal transition and PD-L1 expression. We found that knockdown or pharmacological inhibition of Ly6K by small molecules binders, can significantly inhibit multiple distinct aspects of the biological activity of Ly6K. This proposal will be focused on determining the molecular basis of Ly6K action and Ly6K targeted therapeutics.
Flow cytometry: Sample prep, execution on the machine, data analysis, sorting and multicolor panel
Cell culture: Primary and cell lines, T cell expansion.
In vivo studies: Mouse handling, i.p. injections, tumor injections and
measurements, immunotherapy assays, tissue collection and processing, mouse genetics.
In vitro and ex vivo assays: cell signaling, live cell imaging, westerns, qRT-PCR, luminex.
Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A., 108, 7820–7825 (2011). PMID: 21518866.
AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G. Lymphocyte antigens 6 complex K/E-transforming growth factor-beta axis promotes breast cancer tumorigenesis. Cancer Res., 76, 3376–3386 (2016). PMID: 27197181.
Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G. Lymphocyte antigens 6 complex gene family members drive tumorigenesis. Oncotarget, 7, 11165–11193 (2016). PMID: 26862846
Click here to apply for the postdoctoral position at USUHS website.
Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: email@example.com